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Parkinson’s medication blamed for sexual offences

Parkinson’s medication blamed for sexual offences

Adrian Carter and Wayne Hall, from the Neuroethics group at the University of Queensland Centre for Clinical Research, Australia

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The medication that provides significant relief from debilitating motor disturbances in people with Parkinson’s disease appears to cause a range of psychiatric disturbances that are as distressing and difficult to treat as the motor symptoms they aim to relieve.

Parkinson’s disease is usually treated with dopamine replacement therapy (DRT). This involves daily dosing with either levodopa (a precursor to the neurotransmitter, dopamine) or dopamine agonists (such as pramipexole and ropinirole) that mimic the effects of dopamine in the brain. The aim of DRT is to reduce the effects of the loss of dopaminergic neurons in specific regions of the brain involved in controlling bodily movement. However, dopamine is also a key neurotransmitter in a range of cognitive processes from executive control and memory to motivation and bonding. It is perhaps unsurprising that many Parkinson’s patients experience adverse psychiatric and cognitive side-effects from taking large doses of dopamine every day. 

Parkinson’s patients can experience severe anxiety, depression and mania and have a higher risk of suicide. A significant minority of Parkinson’s patients treated with dopamine replacement therapy will also develop impulsive and compulsive behaviours that appear to be caused by their medication. These include pathological gambling and hypersexuality, and compulsive eating and shopping. In rare cases, patients have committed criminal offences. Read More »Parkinson’s medication blamed for sexual offences

Mind Over ‘Dark’ Matter – The Higgs-Boson & The Value of Theoretical Academic Enquiry

CERN’s recent discovery of a particle consistent with the long sought-after Higgs boson has been hailed as a momentous achievement in physics. According to press releases, the finding provides substantial support for the standard model of the universe, since it explains why the particles proposed by the standard model should have mass. Although the complex physics underlying this explanation may be beyond non-physicists (such as myself), even we lay-people can understand that this finding represents a huge step forward in our understanding of the universe.Read More »Mind Over ‘Dark’ Matter – The Higgs-Boson & The Value of Theoretical Academic Enquiry

Stop Persecuting Armstrong: Time for a Doping Amnesty in Cycling

By Julian Savulescu and Bennett Foddy

The anti-doping witch hunt being perpetrated by the US Anti-Doping Agency (USADA) is ruining cycling. There is a simple solution: an amnesty for dopers and relax anti-doping laws.

The Story So Far

Lance Armstrong has accused the USADA of running a vendetta amidst claims from a Dutch newspaper that 4 former team mates are witnesses against him, all of whom are riding in this year’s Tour de France. Speculation on what was offered to these riders in exchange from their testimony has focussed on a six month ban, delayed until after the Tour de France, though this has been denied. USADA has refused to name any of the 10 witnesses. Lance Armstrong, in a tweet, has labelled the anonymity and immunity offered in exchange for testimony against him as ‘selective prosecution’ and a ‘vendetta’.

Armstrong stands accused of doping violations between 1998 and 2005, and, if found guilty, will face losing all his seven wins, with accusations including the use of EPO, blood transfusions and steroids, following his treatment for cancer and throughout his Tour de France wins. His former team mates Hincapie, Leipheimer, Vande Velde and Zabriskie did not stand for consideration for the United States Olympic team. A two year federal investigation resulted in no charges filed and Armstrong has not failed any drug tests but has been dogged by rumours and accusations for many years.

The fact is though that every winner of the Tour de France has been implicated in doping since Miguel Indurain, except Cadel Evans and Andy Schleck.

Read More »Stop Persecuting Armstrong: Time for a Doping Amnesty in Cycling

Should minimally conscious patients be allowed to end their lives?

Two recent articles by neurobiologist and science writer Mo Costandi raise ethical quesions about the treatment of brain-damaged patients in the light of new research. Doctors distinguish between patients in a vegetative state, who are completely unresponsive and assumed to lack conscious awareness, and patients in a minimally conscious state, who some degree of responsiveness and are assumed to have some awareness – although it is unclear what their experiences are like and what mental abilities they have. A third category of patients are those in a “locked-in” state. These people are fully aware and awake, but paralysed and unable to communicate except through eye movements. Patients in a persistent vegetative state are highly unlikely to recover from it, and in most countries the law allows, under certain conditions, passive euthanasia for this group, for example by disconnecting a feeding tube that provides life support. But is this policy ethically defensible, and should we also allow euthanasia for patients with the other diagnoses?
Read More »Should minimally conscious patients be allowed to end their lives?

Reducing Religious Conflict conference podcasts now available

  Dear all, Podcasts of the papers presented at the recent ‘Reducing Religious Conflict’ conference held in Oxford 18-19 June 2012 are now available at: http://www.src.ox.ac.uk/2012-2conf.htm Presentations at the conference included: Scott Atran, Anthropology (University of Michigan and National Center for Scientific Research Paris) Religious and Sacred Imperatives in Human Conflict Liz Carmichael (Faculty of Theology,… Read More »Reducing Religious Conflict conference podcasts now available

Artificial organs: “good guys” finish last to technology

It is hardly a keen insight to note that there are a lot of problems in the world today, and that there are also lots of suggested solutions. Often these can be classified under three different labels:

  • “Good guy” solutions which rely on changing individual people’s attitudes and behaviours.
  • Institutional solutions which rely on designing good institutions to address the problem.
  • Technological solutions which count on technology to resolve the problem.

In this view, it is tremendously good news that scientists are getting closer to producing artificial organs. If this goal is achieved, it will be a technological solution to the problem of transplant organ shortages – and technological solutions tend to be better than institutional solutions, which are generally much better than “good guy” solutions. The “good guy” solution to organ donation was to count on people to volunteer to donate when they died. Better institutions (such as an opt-out system where you have to make a special effort not to be a donor, rather than a special effort to be a donor) have resulted in much improved donation rates. But cheap artificial organs would really be the ultimate solution.

Of course I don’t denigrate the use of getting people on your side, nor the motivations of those who sincerely want to change things. But changes to people’s attitudes only tend to stick around as long term solutions if this is translated into actual institutional or technological changes.

Take slavery, for instance. Read More »Artificial organs: “good guys” finish last to technology

Après nous, le déluge: legislating science

The North Carolina senate tried to pass a bill in June banning state agency researchers from using exponential extrapolations in predictions of sea level, requiring them to just using linear extrapolations. After being generally laughed at, the legislators settled for a compromise: state agencies were forbidden to base any laws or plans on exponential extrapolations for the next three to four years. Now a new report shows that sea levels are rising faster near North Carolina than anywhere else on Earth.

Read More »Après nous, le déluge: legislating science

Can the religious beliefs of parents justify the nonconsensual cutting of their child’s genitals?

By Brian D. Earp

See Brian’s most recent previous post by clicking here.

See all of Brian’s previous posts by clicking here.

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 See updated material below – reply to a critic. 

Of faith and circumcision: Can the religious beliefs of parents justify the nonconsensual cutting of their child’s genitals?

Circumcising minors on religious grounds amounts to grievous bodily harm according to a German court ruling issued on Tuesday. AFP News reports:

The regional court in Cologne, western Germany, ruled that the “fundamental right of the child to bodily integrity outweighed the fundamental rights of the parents. The religious freedom of the parents and their right to educate their child would not be unacceptably compromised, if they were obliged to wait until the child could himself decide to be circumcised.”

Some Jewish groups are up in arms. They insist that God has “non-negotiably” required that circumcision take place on precisely the eighth day after birth; hence waiting to perform the operation until the child could consent would amount to breaking this keystone covenant with their deity. Using the force of law to delay circumcision, then, is no different from banning it outright, since a delayed circumcision is religiously meaningless.

I don’t find this argument very compelling.

Read More »Can the religious beliefs of parents justify the nonconsensual cutting of their child’s genitals?

Honesty and Science

Honesty is a virtue. The strange thing about honesty is that we do not seem to see even the simplest aspect, telling the truth when it is owed, as a duty. People who would be horrified at hurting anyone will trim, twist, exaggerate and lie at the drop of a hat, especially when it advances their ideological agenda, and will not feel they have done much wrong at all. Worse, they will anathematise those who utter inconvenient truth and feel highly righteous in doing so.

Science can be pure enquiry but the questions it seeks to answer are often those with significant practical import. The reason we subsidise science is because of the benefits it promises. Getting the benefits depends on scientists finding out and telling us the truth. From this point of view, then, honesty is a prime virtue of science and to be honest is a stringent duty owed to us all by scientists. It is unclear to what extent scientists feel properly bound by this duty.Read More »Honesty and Science

Let’s get rid of Heaven, Hell is what we need! (?)

In the beginning of this week, PLoS ONE published an interesting article suggesting that a country’s crime rates depend on the religious believes its population holds: Societies that believe in heaven are more criminal than societies that believe in hell.

For this study, Azim Shariff (director of the Culture and Morality Lab of the University of Oregon) and Mijke Rhemtulla analysed data on people’s beliefs the World Values Surveys collected over 26 years on 143 197 participants from 67 countries. In these surveys, participants were presented a list of concepts – including “heaven” and “hell” – and asked to indicate whether or not they believed in each of them. Shariff & Rhemtulla compared these belief data (using a series of linear regression equations) to standardised crime rates which they derived from statistics the United Nations Office on Drugs and Crime collected on crimes like homicide, robbery, and burglary.

 

Read More »Let’s get rid of Heaven, Hell is what we need! (?)